Celiac Disease Causes And Other Conditions Unknown To People

Celiac Disease Causes And Other Conditions Unknown To People
Intestinal Damage of Gluten

Celiac Disease Causes And Other Conditions Unknown To People; Celiac disease is an autoimmune disorder which occurs due to intolerance to gluten. Gluten is the broad name of the proteins found in wheat, rye, and barley and other grains derived from them. Presence of gluten in the body is a heavy attribute to celiac disease causes and it is estimated to have affected 1 in 100 people globally. Two and one-half million Americans are not diagnosed and are at risk for long-term health complications.

Celiac disease is also known to have various other names which include celiac sprue, gluten-sensitive enteropathy, and non-tropical sprue and which can lead to a broad variety of signs in diverse people. Infants may not acquire weight and height as expected (a condition called failure to thrive). Older kids can have diarrhea, fatigue, abdominal pain and bloating painful skin rashes or weight loss. Some people who have celiac disease have no signs or symptoms at all.

Celiac Disease Causes And Other Conditions Unknown To People

READ ALSO: High Proven Health Benefits of Amaranth- A Gluten-Free, Protein-Rich Plant

Celiac Disease Causes And Other Conditions Unknown To People 

Quick Tips On Celiac Disease

  • In people with celiac disease, inflammation happens in the small intestinal mucosa when it is exposed to gluten in the diet.
  • The symptoms usually engage the digestive system and cause:
  • abdominal discomfort,
  • nausea,
  • bloating, and
  • loose bowel movements.
  • Celiac disease is evidenced to be an autoimmune disorder and may possess a familial or genetic component.
  • However, there is a broad spectrum of signs or symptoms that may occur.
  • Because there is inflammation of the intestine, it may also lose its ability to absorb nutrients from the diet, thereby leading to other associated illnesses.
  • Treatment of celiac disease is via strictly following a gluten-free diet.
  • Celiac disease is also known by other names which include non-tropical sprue, celiac sprue, and gluten enteropathy.

When people with celiac disease consume gluten- a protein discovered in wheat, barley and rye, their body produces an immune response that fights the small intestine. These attacks bring about damage on the villi, small fingerlike projections that line the small intestine and boost nutrient absorption. When damage occurs in the villi, nutrients cannot be absorbed properly into the body.

Celiac disease is a hereditary factor, meaning that it runs in families. People with a first-degree relative with celiac disease (parent, child, sibling) do have a 1 in 10 risks of having celiac disease.


Celiac Disease Causes

Celiac disease causes can be attributed to several factors.

  1. Gluten

Gluten is a protein discovered in wheat, rye, and barley. In some people who are exposed to gluten in their food, an enzyme called tissue transglutaminase changes the gluten into a chemical that produces an immune response, leading to inflammation of the small intestine lining. The normal villi that make up the lining of the intestine are blunted and damaged, thereby preventing the normal absorption of nutrients from the diet.

 ALSO READ: Four Proven Ways Wheat Damages Our Health

  1. Malabsorption of vitamins, minerals and other nutrients

This malabsorption of vitamins, minerals, and other nutrients may cause damage to other organs in the body, such as the liver, brain and bone‘ that rely on those nutrients to function normally. In children, the absence of effective nutrition because of malnutrition can cause abnormal growth and development.


  1. Genetics

There seems to be a genetic connectivity to developing celiac disease, however not all persons with a family history of celiac disease develop the condition. There is another reason, yet to be known, why the autoimmune response occurs.


  1. Diabetes type 1, microscopic colitis, Sjögren’s syndrome and autoimmune thyroid disease

In addition to the history of a family, celiac disease seems to occur more in people with type 1 diabetes, microscopic colitis, Sjögren’s syndrome and autoimmune thyroid disease.

Celiac Disease Causes And Other Conditions Unknown To People

Other Conditions Of Celiac Disease                            

Celiac Disease Signs

Celiac disease usually causes general gastrointestinal discomfort. Symptoms may include the following:

. Constipation

. Bloating

. Diarrhea (occasional or persistent)

. Abdominal cramps

. Gas

. Abdominal cramps

. Itchy, rash in blistering form on the knees, elbows, and buttocks (called dermatitis    herpetiformis, or DH, which is a reaction to gluten in the body system)

. Weight loss

. Stool that is oily or has a grey tinge

. Stomach pain

. Weakness or fatigue

. Loss of appetite

. Lactose intolerance (difficulty digesting milk or foods made with milk)

. Mood changes, depression


In children, signs of the celiac disease may include the above signs, as well as the following:


. Distention of the stomach (potbelly)

. Flat buttocks

. Difficulty concentrating and learning

. Irritability

. Paleness

. Several complicated reactions can occur in patients who have celiac disease, as a result of the body’s inability to take in vitamins, minerals, and other nutrients.  

. Low percentile for height and weight (i.e., not growing as expected for age group)

Celiac Disease Causes And Other Conditions Unknown To People

Complications of celiac disease encompass the following:

. Birth defects (in babies born to mothers with undiagnosed celiac disease)

. Osteoporosis

. Miscarriage

. Short Stature

. Slowed growth (in children)

. Over time, if a patient with celiac disease does not follow a strict, gluten-free diet, damage to the small intestine can cause him or her more serious complications, such as cancer of the intestinal organs (e.g., colorectal cancer).


Treatment Of Celiac Disease

Presently, the only treatment for celiac disease is lifelong adherence to a strict gluten-free diet. People living gluten-free must keep away from foods with wheat, barley and rye, such as bread and beer. Consuming small amounts of gluten, like crumbs from a cutting board or toaster, can trigger small intestine damage.

Undiagnosed or untreated celiac disease can lead to long-term health conditions such as:

. Lactose intolerance

. Vitamin and mineral deficiencies

. Central and peripheral nervous system disorders

. Pancreatic insufficiency

. Iron deficiency anemia

. Gall bladder malfunction

. Neurological manifestations, including ataxia, epileptic seizures, dementia, migraine, neuropathy, myopathy and multifocal leucoencephalopathy

. Early onset osteoporosis or osteopenia

. Infertility and miscarriage

. Intestinal lymphomas and other GI cancers (malignancies)


Sources and references:

  1. Crowe SE. In the clinic. Celiac disease. Ann Intern Med. 2011 May 3;154(9):ITC5-1-ITC5-15; quiz ITC5-16. doi: 10.7326/0003-4819-154-9-201105030-01005. Review. Citation on PubMed
  2. Freeman HJ. Risk factors in familial forms of celiac disease. World J Gastroenterol. 2010 Apr 21;16(15):1828-31. Review. Citation on PubMed or Free article on PubMed Central
  3. Guandalini S, Assiri A. Celiac disease: a review. JAMA Pediatr. 2014 Mar;168(3):272-8. doi: 10.1001/jamapediatrics.2013.3858. Review. Citation on PubMed
  4. Karandish E, Hachem C. Celiac disease. Mo Med. 2009 Sep-Oct;106(5):346-50. Review. Citation on PubMed







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